Research background
FOXO4-DRI is a retro-inverso peptide built from D-amino acids in reversed sequence order, engineered to mimic the FOXO4 interaction surface while resisting proteolysis. It is a standard tool compound in senolytic research.
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FOXO4-DRI 14 mg lyophilized research peptide vial, PRIMEGEN LABS front label. Buy FOXO4-DRI 14 mg from PrimeGen Labs — 98.7% purity lyophilized FOXO4-DRI peptide for laboratory research, third party tested by HPLC and mass spectrometry, supplied in a sealed 10 mL borosilicate vial with a batch-matched certificate of analysis.
Specialty Research
FOXO4-DRI
Senolytic peptide
Low stock · few lots left
D-retro-inverso peptide referenced in p53 interaction and senescent-cell research.
$194.00
- Third-party tested
- Ambient-stable transit
- Lot traceable
- Batch-matched COA
- Tracked delivery
- Research use only
For laboratory research use only. Not for human or veterinary consumption.
Laboratory specifications
- Purity (RP-HPLC)
- 98.7%
- Molecular weight
- ~5194 g/mol
- CAS number
- Not assigned
- Form
- Lyophilized powder
- Appearance
- White to off-white lyophilized powder or cake, free of visible particulates.
- Solubility
- Sterile or bacteriostatic water; DMSO for hydrophobic sequences
- Endotoxin
- < 0.25 EU/mg
- Fill weight
- 14 mg
- Storage temperature
- -20 °C sealed · 2–8 °C after reconstitution
- Shelf life
- 36 months at -20 °C from the manufacture date
- Reconstitution
- Add diluent slowly down the vial wall; do not shake or vortex
- Synthesis
- Solid-phase (SPPS)
- Identity
- ESI-MS confirmed
- Residual solvent
- < 0.5%
- Closure
- Crimped aluminium / butyl stopper
- Manufacturer
- PRIMEGEN LABS · PrimeGen Co.
Storage & handling
Long-term
-20 °C, sealed, desiccated
In transit
Ambient stable up to 21 days
After reconstitution
2–8 °C, use within 21 days
Light exposure
Protect from direct light
Certificate of analysis
Lot XX · HPLC + MS report issued by an independent laboratory. The released PDF is available on request.
- Lot number
- XX
- EXP
- XX/XXXX
- COA date
- On request
- Testing laboratory
- Independent ISO lab
- Purity
- 98.7%
- Testing method
- RP-HPLC + ESI-MS
- Batch status
- Released — report on request
A batch-matched digital certificate for lot XX is available on request.
Mechanism of action
Designed to interfere with the FOXO4-p53 protein-protein interaction that sequesters p53 in the nucleus of senescent cells. Disruption is reported to permit p53 mitochondrial translocation and selective apoptosis of senescent, but not proliferating, cells in culture.
Areas of scientific investigation
- Senolytic screening and senescence-associated beta-galactosidase assays
- FOXO4-p53 protein-protein interaction studies
- Retro-inverso peptide design chemistry
- Cellular ageing models
Listed fields describe where this sequence appears in published in vitro and preclinical literature. They are not indications, applications, or claims of effect.
Laboratory handling
Reconstitution
Supplied lyophilized; typically reconstituted in sterile water or PBS. As a D-amino-acid construct it is markedly protease-resistant, which simplifies long-incubation culture work.
Stability
As a sealed lyophilized powder the material is stable for extended periods at -20 °C when kept desiccated and protected from light. Once in solution, stability shortens considerably: aqueous stocks are normally held at 2-8 °C for short term work or aliquoted and frozen for longer storage. Repeated freeze-thaw cycling is the most common cause of measurable potency loss.
Packaging
Single sequence per vial, sealed under inert gas in USP Type I borosilicate glass with a butyl rubber stopper and crimped aluminium overseal. Each vial carries a printed PRIMEGEN LABS label with product name, strength, lot number, manufacture and retest dates, storage temperature and a QR code linking to the lot record. Vials ship in a rigid foam insert inside a protective mailer at ambient temperature.
Frequently asked questions
Pairs well with
Complementary compounds researchers run alongside FOXO4-DRI — never competing alternatives.
Complete your order
Laboratory consumables matched to 1 vial in your cart.
Bacteriostatic Water
30 mL
1 × 30 mL — one vial of diluent per 3 peptide vials
$16.00
Sterile Syringes
10-pack · 1 mL
10-pack covers a standard order
$13.00
Alcohol Prep Pads
100-pack
Septum decontamination before every draw
$9.00
Vial Storage Case
25 slots
Keeps lots organised and light-protected
$33.00