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MOTS-c 5 mg lyophilized research peptide vial, PRIMEGEN LABS front label. Buy MOTS-c 5 mg from PrimeGen Labs — 99.1% purity lyophilized MOTS-c peptide for laboratory research, third party tested by HPLC and mass spectrometry, supplied in a sealed 10 mL borosilicate vial with a batch-matched certificate of analysis.

Weight Management Research

MOTS-c

Mitochondrial-derived peptide

In stock

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16-amino-acid mitochondrial peptide studied for AMPK activation and metabolic homeostasis.

$20.00
  • Third-party tested
  • Ambient-stable transit
  • Lot traceable
  • Batch-matched COA
  • Tracked delivery
  • Research use only

For laboratory research use only. Not for human or veterinary consumption.

Laboratory specifications

Purity (RP-HPLC)
99.511%
Molecular weight
2174.6 g/mol
Sequence
MRWQEMGYIFYPRKLR
CAS number
1627580-64-6
Form
Lyophilized powder
Appearance
White to off-white lyophilized powder or cake, free of visible particulates.
Solubility
Sterile or bacteriostatic water; DMSO for hydrophobic sequences
Endotoxin
< 0.25 EU/mg
Fill weight
5 mg
Storage temperature
-20 °C sealed · 2–8 °C after reconstitution
Shelf life
36 months at -20 °C from the manufacture date
Reconstitution
Add diluent slowly down the vial wall; do not shake or vortex
Synthesis
Solid-phase (SPPS)
Identity
ESI-MS confirmed
Residual solvent
< 0.5%
Closure
Crimped aluminium / butyl stopper
Manufacturer
PRIMEGEN LABS · PrimeGen Co.

Storage & handling

  • Long-term

    -20 °C, sealed, desiccated

  • In transit

    Ambient stable up to 21 days

  • After reconstitution

    2–8 °C, use within 21 days

  • Light exposure

    Protect from direct light

Certificate of analysis

Janoshik Analytical report #109943 · sample submitted as MOTS-c 10 mg.

Lot number
XX
EXP
XX/XXXX
COA date
19 Feb 2026
Testing laboratory
Janoshik Analytical
Purity
99.511%
Testing method
RP-HPLC + ESI-MS
Batch status
Released
Measured content
11.15 mg
Verification key
RV81TNKLYC5T
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Research background

MOTS-c is a 16-residue peptide encoded within the mitochondrial 12S rRNA gene, one of a small family of mitochondrial-derived peptides identified through alternative open reading frame analysis. Its discovery is frequently cited as evidence that the mitochondrial genome participates in retrograde signalling.

Mechanism of action

Under metabolic stress the peptide translocates to the nucleus and is reported to modulate AMP-activated protein kinase signalling and the folate-methionine cycle, altering the expression of stress-response genes. It is studied as a retrograde mitochondrial-to-nuclear messenger rather than a receptor ligand.

Areas of scientific investigation

  • Mitochondrial-nuclear retrograde signalling
  • AMPK pathway activation studies
  • Skeletal muscle insulin sensitivity models
  • Cellular ageing and metabolic-stress research

Listed fields describe where this sequence appears in published in vitro and preclinical literature. They are not indications, applications, or claims of effect.

Laboratory handling

Reconstitution

Allow the vial to reach room temperature before opening to prevent condensation on the lyophilized cake. Add sterile or bacteriostatic water slowly down the inner wall of the vial, then let the powder dissolve without agitation; swirl gently if needed. Do not shake or vortex — shear forces denature peptide secondary structure and cause foaming that traps material on the stopper.

Stability

As a sealed lyophilized powder the material is stable for extended periods at -20 °C when kept desiccated and protected from light. Once in solution, stability shortens considerably: aqueous stocks are normally held at 2-8 °C for short term work or aliquoted and frozen for longer storage. Repeated freeze-thaw cycling is the most common cause of measurable potency loss.

Packaging

Single sequence per vial, sealed under inert gas in USP Type I borosilicate glass with a butyl rubber stopper and crimped aluminium overseal. Each vial carries a printed PRIMEGEN LABS label with product name, strength, lot number, manufacture and retest dates, storage temperature and a QR code linking to the lot record. Vials ship in a rigid foam insert inside a protective mailer at ambient temperature.

Frequently asked questions

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Laboratory consumables matched to 1 vial in your cart.

  • Bacteriostatic Water — 30 mL

    Bacteriostatic Water

    30 mL

    1 × 30 mL — one vial of diluent per 3 peptide vials

    $16.00
  • Sterile Syringes — 10-pack · 1 mL

    Sterile Syringes

    10-pack · 1 mL

    10-pack covers a standard order

    $13.00
  • Alcohol Prep Pads — 100-pack

    Alcohol Prep Pads

    100-pack

    Septum decontamination before every draw

    $9.00
  • Vial Storage Case — 25 slots

    Vial Storage Case

    25 slots

    Keeps lots organised and light-protected

    $33.00

Research stacks

Stacks that include MOTS-C

  • Weight Management Stack

    Semaglutide 5 mg · AOD-9604 5 mg · MOTS-c 10 mg

    View stack

MOTS-c · 5 mg

In stock

$20.00